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河北工业大学

The midbrain-to-pons ratio distinguishes progressive supranuclear palsy from non-fluent primary progressive aphasias.

Title: The midbrain-to-pons ratio distinguishes progressive supranuclear palsy from non-fluent primary progressive aphasias.
Authors: Silsby M; Concord Hospital, Sydney, NSW, Australia.
Tweedie-Cullen RY; The University of Auckland, Auckland, New Zealand.
Murray CR; Brain and Mind Centre, University of Sydney Medical School, Sydney, NSW, Australia.
Halliday GM; Brain and Mind Centre, University of Sydney Medical School, Sydney, NSW, Australia.; Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Neuroscience Research Australia, Sydney, NSW, Australia.
Hodges JR; Brain and Mind Centre, University of Sydney Medical School, Sydney, NSW, Australia.; Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Burrell JR; Concord Hospital, Sydney, NSW, Australia.; Brain and Mind Centre, University of Sydney Medical School, Sydney, NSW, Australia.; Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Source: European Journal Of Neurology [Eur J Neurol] 2017 Jul; Vol. 24 (7), pp. 956-965. Date of Electronic Publication: 2017 May 16.
Publication Type: Journal Article
Language: English
Journal Info: In Process
Imprint Name(s): : Oxford ; New York : Rapid Communications, [1994-
Abstract: Background and Purpose: To determine the clinical utility of the midbrain-to-pons (M/P) ratio as a clinical biomarker of progressive supranuclear palsy (PSP) in patients with non-fluent primary progressive aphasia syndromes. ; Methods: Patients with PSP, progressive non-fluent aphasia (PNFA) and logopenic progressive aphasia (LPA) were recruited. Patients were diagnosed clinically, but pathological confirmation was available in a proportion of patients. Midbrain and pons areas were measured using Osirix Lite, a free DICOM viewer. The M/P ratio and Magnetic Resonance Parkinsonism Index were calculated and their diagnostic utility compared. ; Results: A total of 72 participants were included (16 PSP, 18 PNFA, 16 LPA and 22 controls). Patients with PSP had motor features typical of the syndrome. Both the M/P ratio and Magnetic Resonance Parkinsonism Index differed significantly in PSP compared with controls. The M/P ratio was disproportionately reduced in PSP compared with PNFA and LPA (PSP, 0.182 ± 0.043; PNFA, 0.255 ± 0.034; LPA, 0.258 ± 0.033; controls, 0.292 ± 0.031; P < 0.001). An M/P ratio of ≤0.215 produced a positive predictive value of 77.8% for the diagnosis of PSP syndrome. Pathological examination revealed Alzheimer's disease in three cases (all LPA), pathological PSP in two cases (one clinical PSP and one PNFA) and corticobasal degeneration in one case (PNFA). The M/P ratio was ≤0.215 in both pathological cases of PSP. ; Conclusions: The M/P ratio was disproportionately reduced in PSP, suggesting its potential as a clinical marker of the PSP syndrome. Larger studies of pathologically confirmed cases are needed to establish the M/P ratio as a biomarker of PSP pathology. ; (© 2017 EAN.)
Contributed Indexing: clinicopathological correlation; hummingbird bird sign; logopenic progressive aphasia; primary progressive aphasia; progressive non-fluent aphasia; progressive supranuclear palsy
Entry Date(s): 20170623
Update Code: 20170623
PMID: 28510312
PageCount: 956-956
volume: 24
issue: 7
issn: 1468-1331
pubdate: 2017
DOI: https://doi.org/10.1111/ene.13314
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